LymphedemaV1, Main, Exploration, bibRecord, 002673

Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model

Identifieur interne : 002673 ( Main/Exploration ); précédent : 002672; suivant : 002674

Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model

Auteurs : Akira Kasuya [Japon] ; Jun-Ichi Sakabe [Japon] ; Yoshiki Tokura [Japon]

Source :

Scientific Reports [ 2045-2322 ] ; 2014.

RBID : PMC:3933905

Abstract

Ischemia-reperfusion (IR) injury is a cause of pressure ulcer. However, a mechanism underlying the IR injury-induced lymphatic vessel damage remains unclear. We investigated the alterations of structure and function of lymphatic ducts in a mouse cutaneous IR model. And we suggested a new method for evaluating the severity of pressure ulcer. Immunohistochemistry showed that lymphatic ducts were totally vanished by IR injury, while blood vessels were relatively preserved. The production of harmful reactive oxygen species (ROS) was increased in injured tissue. In vitro study showed a high vulnerability of lymphatic endothelial cells to ROS. Then we evaluated the impaired lymphatic drainage using an in vivo imaging system for intradermally injected indocyanine green (ICG). The dysfunction of ICG drainage positively correlated with the severity of subsequent cutaneous changes. Quantification of the lymphatic duct dysfunction by this imaging system could be a useful strategy to estimate the severity of pressure ulcer.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933905

DOI: 10.1038/srep04173
PubMed: 24566895
PubMed Central: 3933905

Affiliations:

Japon

Le document en format XML

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<author><name sortKey="Tokura, Yoshiki" sort="Tokura, Yoshiki" uniqKey="Tokura Y" first="Yoshiki" last="Tokura">Yoshiki Tokura</name>
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<front><div type="abstract" xml:lang="en"><p>Ischemia-reperfusion (IR) injury is a cause of pressure ulcer. However, a mechanism underlying the IR injury-induced lymphatic vessel damage remains unclear. We investigated the alterations of structure and function of lymphatic ducts in a mouse cutaneous IR model. And we suggested a new method for evaluating the severity of pressure ulcer. Immunohistochemistry showed that lymphatic ducts were totally vanished by IR injury, while blood vessels were relatively preserved. The production of harmful reactive oxygen species (ROS) was increased in injured tissue. In vitro study showed a high vulnerability of lymphatic endothelial cells to ROS. Then we evaluated the impaired lymphatic drainage using an <italic>in vivo</italic>
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Serveur d'exploration sur le lymphœdème

Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model

Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model

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Abstract

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